Regulatory landscape of enhancer-mediated transcriptional activation
Enhancers are regulatory elements that determine the temporal and spatial specificity of gene transcription.
Enhancers serve as hubs for the transient assembly of transcription factor/coactivator clusters during the induction of transcriptional bursting.
Transcriptional activation by enhancers does not always accompany an increased physical proximity to target promoters.
The formation of higher-order genome architectures fosters ultra-long-range enhancer–promoter communication during cell fate determination.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(24)00020-5
